| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We identified fluvastatin, dasatinib, pazopanib as agents inhibiting the function of oncogenic transcriptional co-activator, YAP/TAZ. They activate Hippo pathway and inhibit their nuclear localization. The sensitivity to these drugs of breast and colon cancer cell lines were correlated with the dependence on YAP/TAZ. Combination of these drugs efficiently reduced viability of MDA-MB-231 breast cancer cell lines. Furthermore, combination of these drugs with classical anti-cancer drugs synergistically reduced the viability of MDA-MB-231. These results suggest that these agents are effective for breast cancer cells with YAP/TAZ activation.
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