CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells.
| Project/Area Number |
26830114
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
Komiya Eriko 順天堂大学, 医学(系)研究科(研究院), 博士研究員 (90647009)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | CD26 / periostin / 細胞遊走 / 浸潤 / 転写調節 / 悪性中皮腫 / 転移 / 生存 |
|---|
| Outline of Final Research Achievements |
Malignant pleural mesothelioma (MPM) is an aggressive malignancy arising from mesothelial lining of pleura. It is generally associated with a history of asbestos exposure and has a very poor prognosis, partly due to the lack of a precise understanding of the molecular mechanisms associated with its malignant behavior. In the present study, we expanded on our previous studies on the enhanced motility and increased CD26 expression in MPM cells, with a particular focus on integrin adhesion molecules. We found that expression of CD26 upregulates periostin secretion by MPM cells, leading to enhanced MPM cell migratory and invasive activity. Moreover, we showed that upregulation of periostin expression results from the nuclear translocation of the transcription factor Twist1, a process that is mediated by CD26-associated activation of Src phosphorylation. These findings may lead to the development of novel therapeutic strategies for MPM.
|
Report
(5 results)
Research Products
(14 results)
-
-
[Journal Article] A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus2017
Author(s)
Komiya, E. Hatano, R. Otsuka, H. Itoh, T. Yamazaki, H. Yamada, T. Dang, N. H. Tominaga, M. Suga, Y. Kimura, U. Takamori, K. Morimoto, C. Ohnuma, K.
-
Journal Title
J Dermatol Sci
Volume: 印刷中
Issue: 3
Pages: 212-221
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
[Presentation] The regulation of pruritus in psoriasis and atopic dermatitis-a possible role for CD26/DPPIV2017
Author(s)
Eriko Komiya, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Yasushi Suga, Utako Kimura, Taketo Yamada, Mitsutoshi Tominaga, Kenji Takamori , Kei Ohnuma, Chikao Morimoto
Organizer
9th World congress on itch
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
[Book] Advances in Medicine and Biology The use of the humanized anti-CD26 monoclonal antibody YS110 as a novel targeted therapy for refractory cancers and immune disorders2018
Author(s)
Ryo Hatano, Kei Ohnuma K, Taketo Yamada, Toshihiro Okamoto, Eriko Komiya, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Noriaki Iwao, Yutaro Kaneko, Nam H. Dang, Chikao Morimoto
Total Pages
44
Publisher
Nova Science Publishers, Inc.
ISBN
9781536133486
Related Report
