Elucidation of mechanism for cell survaival, proliferation and anti-cancer drug resistance in mesothelioma, and its application.
| Project/Area Number |
26830116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Tsujimura Tohru 兵庫医科大学, 医学部, 教授 (20227408)
Sato Ayuko 兵庫医科大学, 医学部, 講師 (20419823)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 悪性中皮腫 / オートファジー / 細胞増殖 / 小胞体ストレス応答 / 細胞増殖、生存 / 抗がん剤抵抗性 |
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| Outline of Final Research Achievements |
Aim of this study is to clarify the role of autophagy in malignant mesothelioma. ① The expression level of LC3 was higher in mesothelioma cell lines compared with nomal mesothelial cells and immortalized mesothelial cell line. ② When we used GFP-LC3 expression mesothelioma cell lines to observe autophagy, autophagy were observed in mesothelioma cell lines by culture of normal medium. GFP-LC3 were increased in mesothelioma cell lines by culture of starvation medium. ③ Autophagy inhibitors suppressed autophagy and cell proliferation in mesothelioma cells.
These results suggest that mesothelioma cells are constantly activated autophagy and related to cell proliferation.
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Report
(3 results)
Research Products
(1 results)
