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Regulation of epigenome via TCA cycle in adipocytes

Research Project

Project/Area Number 26830136
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field System genome science
Research InstitutionThe University of Tokyo

Principal Investigator

Matsumura Yoshihiro  東京大学, 先端科学技術研究センター, 助教 (20375257)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords代謝ネットワーク / エピゲノム / 生活習慣病 / ヒストンメチル化 / 脂肪細胞分化 / TCA回路 / TCAサイクル
Outline of Final Research Achievements

This study reveled that during adipogenesis, the TCA cycle enzyme IDH3, which catalyzes the synthesis of a-ketoglutarate, is induced to elevate cellular a-ketoglutarate level. The elevation of a-ketoglutarate activates histone demethylase KDM4A and facilitates histone demethylation on glycolysis genes. This, in turn, induces glycolysis genes and promotes glycolysis and lipid accumulation. These results suggest that metabolism regulates epigenome during adipogenesis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Int'l Joint Research] Sanford-Burnham Med. Res. Insti.(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015

    • Author(s)
      Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/ncomms8052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.2015

    • Author(s)
      Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., Sakai, J.
    • Journal Title

      Molecular Cell

      Volume: 60 Issue: 4 Pages: 584-596

    • DOI

      10.1016/j.molcel.2015.10.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis.2015

    • Author(s)
      Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 7 Pages: 4163-77

    • DOI

      10.1074/jbc.m114.626929

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.2015

    • Author(s)
      Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
    • Journal Title

      Nat Commun

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipogenesis2016

    • Author(s)
      Yoshihiro Matsumura, Ryo Nakaki, Takeshi Inagaki, Ayano Yoshida, Yuka Kano, Hiroshi Kimura, Toshiya Tanaka1, Shuichi Tsutsumi, Mitsuyoshi Nakao, Takefumi Doi, Kiyoko Fukami, Timothy F. Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Juro Sakai
    • Organizer
      Keystone Symposia Chromatin and Epigenetics
    • Place of Presentation
      Whistler, British Columbia, Canada
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 熱産生関連遺伝子の転写制御におけるエンハンサーの機能解析2015

    • Author(s)
      小山一貴、阿部陽平、松村欣宏、稲垣毅、酒井寿郎
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒストンメチル化酵素SETDB1のユビキチン化修飾2015

    • Author(s)
      鹿野優佳、松村欣宏、吉田文乃、柳茂、稲垣毅、酒井寿郎
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Metabolic Regulation of Histone Demethylation and Glycolysis Gene Expression by Isocitrate Dehydrogenase 3 during Adipogenesis2015

    • Author(s)
      Eko F. Ariyanto、松村欣宏、曽我朋義、稲垣毅、酒井寿郎
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] SETDY Regulates C/EBP alpha Transcription during Adipogenesis2015

    • Author(s)
      馬郡健太、山崎あゆむ、大木翔太郎、松村欣宏、稲垣毅、酒井 寿郎
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞系譜特異的DNAメチル化により形成されるH3K4/H3K9me3クロマチンドメインは脂肪細胞分化を停止させる2015

    • Author(s)
      松村欣宏、吉田文乃、仲木竜、鹿野優佳、稲垣毅、油谷浩幸、酒井寿郎
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lineage-specific gene-body DNA Methylation and non-canonical H3K4/H3K9me3 bivalent domains maintain adipocyte lineage2015

    • Author(s)
      Yoshihiro Matsumura, Ayano Yoshida, Ryo Nakaki, Ken-ichi Wakabayashi, Takeshi Inagaki, Kiyoko Fukami, Hiroyuki Aburatani, Juro Sakai
    • Organizer
      The 40th Naito Conference Epigenetics
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lineage-specific Gene Body DNA Methylation Recruits SETDB1 to Form Non-Canonical Bivalent Chromatin Domains That Inhibit Cebpa and Pparg expression and adipogenesis2015

    • Author(s)
      Yoshihiro Matsumura, Ayano Yoshida, Ryo Nakaki, Ken-ichi Wakabayashi, Takeshi Inagaki, Kiyoko Fukami, Hiroyuki Aburatani, Juro Sakai
    • Organizer
      Deuel Conference on Lipids
    • Place of Presentation
      Monterey, CA, USA
    • Year and Date
      2015-03-03 – 2015-03-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of Isocitrate Dehydrogenase 3 in Regulation of Epigenome and Transcription during Adipogenesis2014

    • Author(s)
      Eko F Ariyanoto, Yoshihiro Matsumura Tomoyoshi Soga, Takeshi Inagaki, Juro Sakai
    • Organizer
      The 37th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] SETDB1は新規のクロマチンドメインを形成することでCepbaの転写と脂肪細胞分化を制御する2014

    • Author(s)
      松村欣宏、吉田文乃、仲木竜、鹿野優佳、若林賢一、稲垣毅、深見希代子、油谷浩幸、酒井寿郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒストンメチル化酵素SETDB1のユビキチン化修飾2014

    • Author(s)
      鹿野優佳、松村欣宏、吉田文乃、柳茂、稲垣毅、酒井寿郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] SETDB1 regulates metabolic switch of preadipocytes to adipocytes through repression of Cebpα2014

    • Author(s)
      松村欣宏
    • Organizer
      第11回インスリン抵抗性とメタボリックシンドローム研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-05 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Remarks] 寒冷刺激時の体温維持には熱産生遺伝子の高次構造変化が必須

    • URL

      http://www.lsbm.org/news/2015/0512.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 脂肪細胞の分化を調節する新規のクロマチン構造の解明

    • URL

      http://www.lsbm.org/news/2015/1225.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] FBXL10/KDM2Bタンパクは脂肪細胞分化を制御する

    • URL

      http://www.lsbm.org/news/2014/1226.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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