| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we established an in vitro protein synthesis/folding coupled system reconstituted with purified human translational factors and molecular chaperones. Using this system, we successfully identify the molecular chaperones that are essential for co- or post-translational folding of human nascent proteins. Thus, our in vitro approach can be a useful tool to analyze the molecular mechanisms of protein conformational disorders such as Alzheimer’s disease, Parkinson's disease and Huntington's disease.
|
