| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Aberrant and non-functional mRNA are furequently generated in the cell due to error during mRNA biogenesis process. Co-translational quality control system monitors translation and immediately eliminates aberrant or non-functional mRNA and nascent product before translation is complete. Translation of poly(A) tail is one of the aborted translation in the cell, and generates poly-lysine peptide, inducing translation arrest and rapidly degradation of nascent peptides. However, the mechanism underlaying recognition such an abnormal translation remain poorly understood. In this project, I have identified novel factors involved in the recognition of aborted translation and induction of quality control system to remove generating non-functional nascent products.
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