Biochemical analysis of mRNA quality control in S. cerevisiae
Project/Area Number |
26840002
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Molecular biology
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | リボソーム / 品質管理 / 新生鎖 / ribosome / nascent peptide / quality control |
Outline of Final Research Achievements |
Aberrant and non-functional mRNA are furequently generated in the cell due to error during mRNA biogenesis process. Co-translational quality control system monitors translation and immediately eliminates aberrant or non-functional mRNA and nascent product before translation is complete. Translation of poly(A) tail is one of the aborted translation in the cell, and generates poly-lysine peptide, inducing translation arrest and rapidly degradation of nascent peptides. However, the mechanism underlaying recognition such an abnormal translation remain poorly understood. In this project, I have identified novel factors involved in the recognition of aborted translation and induction of quality control system to remove generating non-functional nascent products.
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Report
(3 results)
Research Products
(3 results)