Molecular mechanism of genome maintenance by histone H1 ubiquitination
| Project/Area Number |
26840003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Kato Kohsuke 筑波大学, 医学医療系, 助教 (90466673)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ゲノム安定性 / ヒストンH1 / ユビキチン / クロマチン / G1-S遺伝子群 / 転写 / G1/S遺伝子群 / 遺伝子 / 細胞周期 |
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| Outline of Final Research Achievements |
Aim of this research is to reveal the molecular mechanism of genome maintenance through the VprBP-mediated histone H1 ubiquitination. Depletion of VprBP caused the accumulation of DNA damage and cell cycle arrest at late S-G2 phase in cells. We found that VprBP is involved in transcription elongation of activating E2F and homologous recombination-repair genes in histone H1-dependent manner. These results raise a possibility that VprBP-mediated histone H1 ubiquitination is involved in genome maintenance through the transcriptional regulation of genes activated in cell cycle G1-S phases.
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Report
(3 results)
Research Products
(2 results)
