| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We found that CEP97 is phosphorylated by Aurora kinase. We also found CEP97 binding protein which are the spindle regulated factor, NEDD1and the centromere regulated factor, SUGT1.The association between CEP97 and NEDD1 is depended on phosphorylation. NEDD1 regulates the localization of CEP97, that has important role for the formation of spindle in mitosis.
We identified a Auorara phosphorylation site S387. The role of S387 is remain unknown. However we found other phosphorylated sites of CEP97 which are probably phosphorylated by CDK1 or PLK1 and possibly regulate formation of spindle in mitosis .
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