Analysis of intron-retaining form of DNA repair-related mRNAs

Research Project

Project/Area Number	26840008
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Molecular biology
Research Institution	Hokkaido University (2015) Kyoto University (2014)
Principal Investigator	Ninomiya Kensuke 北海道大学, 遺伝子病制御研究所, 助教 (00437279)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	スプライシング / ストレス応答 / RNAプロセシング / 遺伝子発現制御 / DNA損傷修復
Outline of Final Research Achievements	Signal-induced splicing of nuclear intron-retaining RNA is a novel regulation mechanism of gene expression. However, it was still unclear what kinds of genes are controlled in a similar manner. Next generation sequencing and bioinformatics analyses revealed that some of promising candidates for novel intron-retaining RNAs are related to DNA damage response and regulated by DNA damage agents.

Report

(3 results)