Research Project
Grant-in-Aid for Young Scientists (B)
Most of a cell’s energy is generated in the compartment of the cell called mitochondria. Mitochondria contain a small circle of DNA, called mitochondrial DNA (mtDNA), that is essential for energy production to maintain life. The significance of mtDNA maintenance can be recognized by the fact that abnormalities in mtDNA are associated with human pathology. A deeper understanding of how mtDNA is replicated and maintained is thus important for the progress of bioscience and medicine. This research project was aimed at finding a new protein factor(s) that are involved in the replication and/or maintenance of mtDNA. To this end, methods for purifying mtDNA-protein complexes were constructed. Then attempts were made to capture proteins that were contained in the complexes, followed by determination of the identity of the proteins. Further, whether the proteins are involved in mtDNA replication or maintenance were examined.
All 2017 2016 2015 Other
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 2 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results, Invited: 2 results) Remarks (3 results)
医学のあゆみ
Volume: 260 Pages: 5-10
Proceedings of the National Academy of Sciences
Volume: 113 Issue: 30
10.1073/pnas.1600537113
The Journal of Biochemistry
Volume: N/A Issue: 1 Pages: 49-57
10.1093/jb/mvw010
40020880721
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