Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Outline of Final Research Achievements |
To trace structural changes of carbonmonoxy hemoglobin associated with ligand photolysis, the X-ray crystallography under laser irradiation conditions were carried out. Using a set of coordinates of those intermediate states of hemoglobin, the quantitative conformation change in inner subunit and intra subunits of hemoglobin were appraised. The sequential structural change in each subunit propagated across the overall tetrameric molecule and produced the quaternary conformational motion.
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