Regulation of gene transcription by the voltage gated calcium channels activation.
Project/Area Number |
26840032
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
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Research Institution | Kyoto University |
Principal Investigator |
Kurokawa Tatsuki 京都大学, 工学(系)研究科(研究院), 助教 (40527701)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | イオンチャネル / カルシウム / 膜電位 / 遺伝子発現制御 |
Outline of Final Research Achievements |
Recently, our laboratory showed a new signaling pathway that the voltage gated calcium channels (VGCC) β4 subunit accumulates in the nucleus and acquires a gene regulatory function under membrane depolarization (Tadmouri et al EMBO J., 2012). These findings demonstrate that an intact VGCC subunit acts as a repressor recruiting platform to control neuronal gene expression. The aim of this project is to resolve the mechanism of a new and important signaling pathway that links the VGCC activation to gene transcription.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] A potent and site-selective agonist of TRPA1.2015
Author(s)
Takaya, J., Mio, K., Shiraishi, T., Kurokawa, T., Otsuka, S., Mori, Y., Uesugi, M.
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Journal Title
J. Am. Chem. Soc.
Volume: 137
Issue: 50
Pages: 15859-15864
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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