| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Recently, our laboratory showed a new signaling pathway that the voltage gated calcium channels (VGCC) β4 subunit accumulates in the nucleus and acquires a gene regulatory function under membrane depolarization (Tadmouri et al EMBO J., 2012). These findings demonstrate that an intact VGCC subunit acts as a repressor recruiting platform to control neuronal gene expression. The aim of this project is to resolve the mechanism of a new and important signaling pathway that links the VGCC activation to gene transcription.
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