| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Heparan sulfate proteoglycans (HSPGs) are glycoproteins composed of a core protein with covalently attached heparan sulfate (HS) chains. HSPGs mediate interactions with a variety of extracellular ligands and participate in many physiological processes. In human, mutations in the lysosomal enzymes that degrade HS result in mucopolysaccharidosis, cause various organ dysfunction. Here, we examined the role of HS degradation during development using Drosophila melanogaster as a model system. We found that mutations in iduronidase, encoding a HS degradation enzyme, reduce the activity of BMP signaling and affect wing development.
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