Development of a built-in type nucleotide which induces a structural change in a motor protein by light irradiation
| Project/Area Number |
26840044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Hokuriku University (2015)
Hokkaido University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | フォトクロミック分子 / モータータンパク質 / ヌクレオチドアナログ |
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| Outline of Final Research Achievements |
I have attempted to synthesize nucleotide derivatives which induce structural changes in a motor protein via photo-irradiations. Targe compounds were designed to consist of a covalently binding unit to the protein, a photo-responesive unit and a nucleotide unit. At this stage, I succeded in synthesizing several chimeric compounds consists of the covalently binding unit and the photo-responsive unit. However, the target compounds have not been obtained. Synethesis and purification methods of the final target nucleotide derivatives coupled with the chimeric units are under investigation.
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Report
(3 results)
Research Products
(3 results)
