| Project/Area Number |
26840063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
Kiyomitsu Tomomi 名古屋大学, 理学(系)研究科(研究院), 助教 (10503443)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞分裂 / 紡錘体配置 / 染色体派生シグナル / Ran-GTP / RCC1 / RanGTP / NuMA |
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| Outline of Final Research Achievements |
Clonal expansion by symmetric cell division is a basis of multi-cellular organisms including humans. In this proposed research, we have studied how chromosome-derived Ran-GTP signals control cortical proteins, NuMA and Anillin, and achieve symmetric cell division in human cells. Importantly, we identified essential domain on NuMA required for Ran-GTP-based regulation, and novel Anillin binding proteins. In addition, we established a human cell line in which chromosome-derived Ran-GTP signals are disrupted during mitosis. These original results will be powerful tools for understanding the mechanisms of symmetric cell division in human cells.
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