Mechanism of fetal lung branching morphogenesis through mitotic cells and Wnt signaling
| Project/Area Number |
26840066
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
Fumoto Katsumi 大阪大学, 医学(系)研究科(研究院), 助教 (40467783)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | Wntシグナル / 分岐形態形成 / 肺 / 発生 / 細胞骨格 / 細胞極性 / 上皮組織 / 分裂細胞 / 細胞分裂 / アクトミオシン |
|---|
| Outline of Final Research Achievements |
Branching morphogenesis in lung is critical tissue morphogenesis to generate the epithelial tubular structures. Although Wnt signaling has been known to regulate lung branching morphogenesis, the role of Wnt signaling in the regulation of cellular function has been unclear. In this study, by using the cultured lung epithelium, I aim to study the cellular processes in branching morphogenesis regulated by Wnt signaling. I found that Wnt signaling regulates the apical cytoskeletal organization and apical-basal polarization, thereby modulating the bud formation by restricting the mitotic cell dependent tissue bending. This study proposes the concept and analytical methodology for cellular function regulated by the growth factor signaling pathways in tissue morphogenesis.
|
Report
(3 results)
Research Products
(6 results)
-
[Journal Article] Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways2016
Author(s)
Anna Blokhuis, Max Koppers, Ewout Groen, Dianne Van den Heuvel, Stefano Dini Modigliani, Jasper Anink, Katsumi Fumoto, Peter Sodaar, Bert Verheijen, Jeroen Demmers, Jan Veldink, Eleonora Aronica, Irene Bozzon, Jeroen Den Hertog, Leonard Van den Berg, Jeroen Pasterkamp
-
Journal Title
Acta Neuropathologica
Volume: 未定
Related Report
Peer Reviewed
-
[Journal Article] CKAP4 is involved in tumor progression as a Dickkopf1 receptor2016
Author(s)
Hirokazu Kimura, Katsumi Fumoto, Kensaku Shojima, Satoshi Nojima, Yoshihito Osugi, Hideo Tomihara, Hidetoshi Eguchi, Yasushi Shintani, Hiroko Endo, Masahiro Inoue, Yuichiro Doki, Meinoshin Okumura, Eiichi Morii, and Akira Kikuchi
-
Journal Title
Journal Clinical Investigation
Volume: 未定
Related Report
Peer Reviewed
-
-
-
-
