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Mechanism of fetal lung branching morphogenesis through mitotic cells and Wnt signaling

Research Project

Project/Area Number 26840066
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionOsaka University

Principal Investigator

Fumoto Katsumi  大阪大学, 医学(系)研究科(研究院), 助教 (40467783)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsWntシグナル / 分岐形態形成 / 肺 / 発生 / 細胞骨格 / 細胞極性 / 上皮組織 / 分裂細胞 / 細胞分裂 / アクトミオシン
Outline of Final Research Achievements

Branching morphogenesis in lung is critical tissue morphogenesis to generate the epithelial tubular structures. Although Wnt signaling has been known to regulate lung branching morphogenesis, the role of Wnt signaling in the regulation of cellular function has been unclear. In this study, by using the cultured lung epithelium, I aim to study the cellular processes in branching morphogenesis regulated by Wnt signaling. I found that Wnt signaling regulates the apical cytoskeletal organization and apical-basal polarization, thereby modulating the bud formation by restricting the mitotic cell dependent tissue bending. This study proposes the concept and analytical methodology for cellular function regulated by the growth factor signaling pathways in tissue morphogenesis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways2016

    • Author(s)
      Anna Blokhuis, Max Koppers, Ewout Groen, Dianne Van den Heuvel, Stefano Dini Modigliani, Jasper Anink, Katsumi Fumoto, Peter Sodaar, Bert Verheijen, Jeroen Demmers, Jan Veldink, Eleonora Aronica, Irene Bozzon, Jeroen Den Hertog, Leonard Van den Berg, Jeroen Pasterkamp
    • Journal Title

      Acta Neuropathologica

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CKAP4 is involved in tumor progression as a Dickkopf1 receptor2016

    • Author(s)
      Hirokazu Kimura, Katsumi Fumoto, Kensaku Shojima, Satoshi Nojima, Yoshihito Osugi, Hideo Tomihara, Hidetoshi Eguchi, Yasushi Shintani, Hiroko Endo, Masahiro Inoue, Yuichiro Doki, Meinoshin Okumura, Eiichi Morii, and Akira Kikuchi
    • Journal Title

      Journal Clinical Investigation

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺上皮管腔組織の分岐における頂底極性制御機構とその意義2015

    • Author(s)
      麓 勝己、菊池 章
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Possible involvement of Wnt signaling in lung branching morphogenesis through apical-basal polarization2015

    • Author(s)
      Katsumi Fumoto and Akira Kikuchi
    • Organizer
      The Second International Meeting for Epithelial Tubulology
    • Place of Presentation
      北海道大学
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Wntシグナルによる肺分岐形態形成制御機構2014

    • Author(s)
      麓 勝己
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] CKAP4を標的とした抗腫瘍剤2016

    • Inventor(s)
      菊池 章
    • Industrial Property Rights Holder
      菊池 章
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-01-28
    • Related Report
      2015 Annual Research Report
    • Overseas

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Published: 2014-04-04   Modified: 2017-05-10  

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