| Project/Area Number |
26840069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Fukuda Tomoyuki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90415282)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | TOR / TORC1 / TORC2 / 低分子量GTPase / シグナル伝達 / 細胞増殖 |
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| Outline of Final Research Achievements |
TOR complex controls cellular functions such as cell survival, growth, and metabolism. TOR kinase is the catalytic subunit of TOR complex and its activity is thought to be regulated by multiple factors and signaling pathways in response to nutrient availability and growth factors. With an aim of identifying novel mechanisms that regulate TOR complex activity, biochemical and genetic screens were performed using fission yeast. The screenings identified various factors that potentially regulate the TOR complex signaling pathway either positively or negatively. Detailed analysis will be performed to reveal the molecular mechanism of each regulation.
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