Estimating mechanical properties of moving cell sheets
| Project/Area Number |
26840077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
Kondo Yohei 京都大学, 情報学研究科, 特定助教 (00724444)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 組織力学 / 逆問題 / 時系列解析 / 機械学習 / 発生生物学 / 組織レオロジー / 細胞集団運動 |
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| Outline of Final Research Achievements |
Measurement of biophysical parameters of living tissues such as rigidity often requires exogenous manipulation on the tissues, but such a manipulation perturbs spontaneous morphological processes undesirably. Here, we developed a non-invasive statistical method to estimate biophysical parameters. Our strategy is to model the tissue as a continuum mechanical system, and to use time-lapse imaging data of tissue dynamics in order to compute the maximum likelihood estimates of model parameters. We validated our method on epithelial spreading of Madin-Darby canine kidney cells, a well-known model system for collective migration.
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Report
(4 results)
Research Products
(4 results)
