Mathematical modeling of collective cell movement
| Project/Area Number |
26840085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kanazawa University (2015-2016)
The Institute of Physical and Chemical Research (2014) |
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Principal Investigator |
Uriu Koichiro 金沢大学, 自然システム学系, 助教 (90726241)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 細胞移動 / 数理モデル / 画像解析 / 遺伝子発現リズム / 同期 / 時間スケール / シミュレーション / トラッキング / 位相振動子 / cell mixing / 数値シミュレーション / 国際情報交換 / ブエノスアイレス / ロンドン |
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| Outline of Final Research Achievements |
We studied collective cell movement in development using mathematical modeling and embryonic imaging data. We developed a novel nuclear segmentation algorithm for cell tracking and a method to validate the accuracy of segmentation algorithms. Using the approach, we quantified cell movement in the zebrafish presomitic mesoderm and constructed a physical model that reproduced observed cell movement patterns. Furthermore, by using mathematical models, we revealed that collective cell movement in the tissue could enhance synchronization of gene expression rhythms across a cell population, suggesting a biological relevance of collective cell movement in development.
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Report
(4 results)
Research Products
(17 results)
