| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We studied collective cell movement in development using mathematical modeling and embryonic imaging data. We developed a novel nuclear segmentation algorithm for cell tracking and a method to validate the accuracy of segmentation algorithms. Using the approach, we quantified cell movement in the zebrafish presomitic mesoderm and constructed a physical model that reproduced observed cell movement patterns. Furthermore, by using mathematical models, we revealed that collective cell movement in the tissue could enhance synchronization of gene expression rhythms across a cell population, suggesting a biological relevance of collective cell movement in development.
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