| Project/Area Number |
26840112
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIROI MAKOTO 東京大学, 分子細胞生物学研究所, 助教 (80597831)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 記憶・学習 / ショウジョウバエ / 嗅覚 / 味覚 / 神経可塑性 / カルシウムイメージング / 神経生物学 / 匂い記憶 |
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| Outline of Final Research Achievements |
Neural plasticity is a key feature of neurons tο establish learning and memory and, in Drosophila olfactory memory, it has been known that the Mushroom body (MB) plays a pivotal role. To understand the neural circuits, I established a live calcium imaging setup where cellular activities from neurons of MB are simultaneously being monitored before, during and after a training session. Our lab has focused on MB cells with CREB-positive (CRE-p cells) and analyzed activities on the CRE-p related cells in this study. 1) Recordings from dopaminergic neurons that sends their dendrites to CRE-p cells. 2) Recordings from output neurons (MBONs) from CRE-p MB cells. 3) I found that at least 2 MBONs showed training-related plasticity. 4) The 2 MBONs shows an opposite plasticity after a training - one increases and the other decreases responses to a learned odor.
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