| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
It has been reported that an AmnSINE1-derived sequence, AS021, serves as an enhancer of Satb2 in corpus callosum of mammals. However, its detailed molecular mechanism remains unknown. In this work, function of an AS021 binding protein and the expression pattern of the related genes in the AS021 deficient mice were revealed. These results will be a quite important basis for understanding of the impact of AmnSINE1-derived enhancers on the gene regulatory network during mammalian evolution.
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