Functional analysis of a retroposon involved in corpus callosum development
| Project/Area Number |
26840117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 発現制御 / 反復配列 / 脳梁 / レトロポゾン / 分子進化 / 哺乳類 / 大脳新皮質 / 脳 |
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| Outline of Final Research Achievements |
It has been reported that an AmnSINE1-derived sequence, AS021, serves as an enhancer of Satb2 in corpus callosum of mammals. However, its detailed molecular mechanism remains unknown. In this work, function of an AS021 binding protein and the expression pattern of the related genes in the AS021 deficient mice were revealed. These results will be a quite important basis for understanding of the impact of AmnSINE1-derived enhancers on the gene regulatory network during mammalian evolution.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate.2016
Author(s)
Nishihara H., Kobayashi N., Kimura-Yoshida C., Yan K., Bormuth O., Ding Q., Nakanishi A., Sasaki T., Hirakawa M., Sumiyama K., Furuta Y., Tarabykin V., Matsuo I., and Okada N.
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Journal Title
PLoS Genet.
Volume: 12(10)
Issue: 10
Pages: 1-17
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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