| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
The role of flagella exhibited by motile lactobacilli was investigated in this research. Non-motile mutant of Lactobacillus agilis showed less colonization or persistence at gastrointestinal tract in mice. Chemotaxis of L. agilis on gut-originated substances implied that the characteristics might help the bacteria to survive in the gut. Unlike flagella of many pathogenic bacteria, the flagellar protein of L. agilis is barely responsive to immune cells, which may be preferable as commensal bacteria. In conclusion, the flagella of motile lactobacilli likely contribute to the colonization in the gastrointestinal tract without eliciting inflammation of the host.
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