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Novel insights into proteins controlling chromosome structure and gene expression in Archaea

Research Project

Project/Area Number 26850057
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied microbiology
Research InstitutionOsaka Dental University

Principal Investigator

MARUYAMA Hugo  大阪歯科大学, 歯学部, 助教 (90610296)

Research Collaborator ATOMI Haruyuki  京都大学, 工学研究科, 教授
HIGASHIBATA Hiroki  東洋大学, 准教授
YAN Jie  シンガポール大学, 教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアーキア / 染色体タンパク質 / 遺伝子発現 / 染色体
Outline of Final Research Achievements

Archaea constitutes the third domain of life. Although chromosome architecture of Archaea is believed to be a primitive version of eukaryotic chromosome system, control of gene expression is currently only understood as activation and repression by transcription factors. Archaeal proteins that control both chromosome architecture and gene expression are starting to be understood. In this research, I tried to elucidate the mechanism underlying this coordinated control of chromosome structure and function.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] Natinal University of Singapore(Singapore)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Complete Genome Sequence of Rothia aeria Type Strain JCM 11412, Isolated from Air in the Russian Space Laboratory Mir.2016

    • Author(s)
      Nambu T, Tsuzukibashi O, Uchibori S, Yamane K, Yamanaka T, Maruyama H, Wang PL, Mugita N, Morioka H, Takahashi K, Komasa Y, Mashimo C.
    • Journal Title

      Genome Announcements

      Volume: 4 Issue: 6

    • DOI

      10.1128/genomea.01444-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome Sequence of Actinomyces naeslundii Strain ATCC 27039, Isolated from an Abdominal Wound Abscess.2016

    • Author(s)
      Mashimo C, Yamane K, Yamanaka T, Maruyama H, Wang PL, Komasa S, Okazaki J, Nambu T.
    • Journal Title

      Genome Announc

      Volume: 4(6) Issue: 6

    • DOI

      10.1128/genomea.01443-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete Genome Sequence of Prevotella intermedia Strain 17-22015

    • Author(s)
      Nambu T, Yamane K, Maruyama H, Mashimo C, Yamanaka T.
    • Journal Title

      Genome Announc

      Volume: 3 Issue: 4

    • DOI

      10.1128/genomea.00951-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcriptional Repressor TrmBL2 from Thermococcus kodakarensis Forms Filamentous Nucleoprotein Structures and Competes with Histones for DNA Binding in a Salt- and DNA Supercoiling-dependent Manner2015

    • Author(s)
      Efremov AK, Qu Y, Maruyama H, Lim CJ, Takeyasu K, Yan J.
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 25 Pages: 15770-84

    • DOI

      10.1074/jbc.m114.626705

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The Roles of TrmBL2 protein on Chromosome Architecture and Protection in Thermococcus kodakarensis2016

    • Author(s)
      Hugo Maruyama, Takashi Kushida, Hiroki Higashibata, Artem K. Efremov, Jie Yan, Haruyuki Atomi, Kunio Takeyasu
    • Organizer
      11th International Congress on Extremophiles
    • Place of Presentation
      Kyoto University Clock Tower Centennial Hall (Kyoto, Japan)
    • Year and Date
      2016-08-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of Histone and TrmB-like protein in chromosome organization of Thermococcus kodakarensis2015

    • Author(s)
      Maruyama H, Efremov AK, Qu Y, Lim CJ, Takeyasu K, Yan J.
    • Organizer
      Gordon Research Conference. Archaea; Ecology, Metabolism & Molecular Biology
    • Place of Presentation
      Newry, Maine, USA
    • Year and Date
      2015-07-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role of Histone and TrmB-like proteins in chromosome organization of Thermococcus kodakarensis2014

    • Author(s)
      Hugo Maruyama, Kunio Takeyasu, Haruyuki Atomi, Hisanori Fukushima, Nicholas A. Kent
    • Organizer
      10th International Congress on Extremophiles
    • Place of Presentation
      Saint Petersburg, Russia
    • Year and Date
      2014-09-07 – 2014-09-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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