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Elucidation and application of regulation mechanism of lipid dynamics at the organelle level

Research Project

Project/Area Number 26850064
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied biochemistry
Research InstitutionKyoto University

Principal Investigator

Masahide Oku  京都大学, (連合)農学研究科(研究院), 助教 (10511230)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオートファジー / 脂肪滴 / 中性脂質 / リポリシス
Outline of Final Research Achievements

This research project, aiming at gaining insights with regard to improvement in oil production by microorganisms, and new aspects of lipid metabolism in eukaryotic cells, focused on the involvements of autophagy-related (Atg) proteins in dynamics of neutral lipids, and that of lipid droplets, the organelle for the accumulation of the lipids in yeasts. This project succeeded in the identification of two Atg proteins acting on the maintenance of lipid droplet amounts, and also in the elucidation of molecular mechanism as to how these proteins regulate lipolysis (hydrolysis of neutral lipids inside the lipid droplets by lipases associated to the organelle).

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (1 results) Remarks (2 results)

  • [Journal Article] Pexophagy in yeasts2016

    • Author(s)
      Masahide Oku, and Yasuyoshi Sakai
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1863 Issue: 5 Pages: 992-998

    • DOI

      10.1016/j.bbamcr.2015.09.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis2015

    • Author(s)
      Yuichiro Maeda, Masahide Oku, and Yasuyoshi Sakai
    • Journal Title

      Autophagy

      Volume: 11 Issue: 8 Pages: 1247-1258

    • DOI

      10.1080/15548627.2015.1056969

    • NAID

      120005702804

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.2014

    • Author(s)
      Aihara M, Jin X, Kurihara Y, Yoshida Y, Matsushima Y, Oku M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Yamamoto T, Sakai Y, Kang D, Kanki T.
    • Journal Title

      Journal of Cell Science

      Volume: 127 Pages: 3184-96

    • DOI

      10.1242/jcs.153254

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 出芽酵母Saccharomyces cerevisiae における脂肪滴の動態制御2014

    • Author(s)
      奥 公秀、前田 佑一郎、阪井 康能
    • Organizer
      日本農芸化学会創立90周年・関西支部創立80周年記念大会
    • Place of Presentation
      奈良先端科学技術大学院大学
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Remarks] 京都大学大学院農学研究科 応用生命科学専攻 制御発酵学分野

    • URL

      http://www.seigyo.kais.kyoto-u.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都大学大学院 農学研究科 応用生命科学専攻 制御発酵学分野

    • URL

      http://www.seigyo.kais.kyoto-u.ac.jp/publications/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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