Elucidation and application of regulation mechanism of lipid dynamics at the organelle level
| Project/Area Number |
26850064
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
Masahide Oku 京都大学, (連合)農学研究科(研究院), 助教 (10511230)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オートファジー / 脂肪滴 / 中性脂質 / リポリシス |
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| Outline of Final Research Achievements |
This research project, aiming at gaining insights with regard to improvement in oil production by microorganisms, and new aspects of lipid metabolism in eukaryotic cells, focused on the involvements of autophagy-related (Atg) proteins in dynamics of neutral lipids, and that of lipid droplets, the organelle for the accumulation of the lipids in yeasts. This project succeeded in the identification of two Atg proteins acting on the maintenance of lipid droplet amounts, and also in the elucidation of molecular mechanism as to how these proteins regulate lipolysis (hydrolysis of neutral lipids inside the lipid droplets by lipases associated to the organelle).
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.2014
Author(s)
Aihara M, Jin X, Kurihara Y, Yoshida Y, Matsushima Y, Oku M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Yamamoto T, Sakai Y, Kang D, Kanki T.
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Journal Title
Journal of Cell Science
Volume: 127
Pages: 3184-96
DOI
Related Report
Peer Reviewed / Open Access
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