| Project/Area Number |
26850073
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 植物免疫活性化剤 / 植物免疫活性剤 |
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| Outline of Final Research Achievements |
Priming plays an important role in plant defense. Priming state is induced by primary infection with pathogen and elicits strong resistance against secondary pathogen attack. Plant activator is chemical that induces the priming state in noninfected plants. Compared with bactericide and insecticide, plant activators have advantage of avoidance of drug-resistance pathogen and protection of microbes in the field.
We established a new high-throughput screening method to identify novel lead compounds for plant activator. From a total of 10,000 compounds screened, we selected 58 candidates for plant activator. The selected compounds enhanced the expression of defense-related genes in Arabidopsis. Furthermore, we examined the effects of the compounds on reactive oxygen species (ROS) production in SA biosynthesis or signal transduction mutants.
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