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Synthetic study of novel antibiotics derived from natural products using cluster effect

Research Project

Project/Area Number 26850074
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioorganic chemistry
Research InstitutionTohoku University (2015)
National Institute of Advanced Industrial Science and Technology (2014)

Principal Investigator

ENOMOTO Masaru  東北大学, (連合)農学研究科(研究院), 准教授 (90546342)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsクラスター効果 / 天然物 / 金ナノ粒子 / 抗菌物質 / ケモセンサー / 抗菌活性 / プラジマイシン
Outline of Final Research Achievements

Multivalent interaction that enhances affinity between proteins and ligands is called a cluster effect. We evaluated the binding affinity and antifungal activity of PRM-AuNPs, which was synthesized by functionalizing gold nanoparticles (AuNPs) with pradimicin (PRM), antifungal and anti-HIV natural product. Consequently, the binding affinity of PRM-AuNPs to mannose (Man) was found to increased ten times as strong as the case of PRM although the antifungal activity of PRM-AuNPs was slightly decreased. Moreover, by making use of the distance-dependent optical properties of AuNPs as well as the Man-specific binding ability of PRM, we have developed a chemosensor that was capable of recognizing mannose residues in oligosaccharides.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] First synthesis of BU-4664L2015

    • Author(s)
      Yusuke Takahashi, Takafumi Hirokawa, Mai Watanabe, Satomi Fujita, Yusuke Ogura, Masaru Enomoto and Shigefumi Kuwahara
    • Journal Title

      Tetrahedron Letters

      Volume: 56 Issue: 41 Pages: 5670-5672

    • DOI

      10.1016/j.tetlet.2015.08.070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mannose-recognizable chemosensor using gold nanoparticles functionalized with pradimicin, a nonpeptidic mannose-binding natural product2015

    • Author(s)
      Masaru Enomoto, Yasuhiro Igarashi, Masahide Sasaki, Hiroki Shimizu
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 18 Pages: 2603-2609

    • DOI

      10.1016/j.tet.2015.03.055

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] クラスター効果を利用した創薬研究2015

    • Author(s)
      榎本賢
    • Journal Title

      有機合成化学協会誌

      Volume: 73 Pages: 388-389

    • NAID

      130005070690

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Mannose-recognizable chemosensor using gold nanoparticles functionalized with pradimicin, a nonpeptidic mannose-binding natural product2015

    • Author(s)
      Masaru Enomoto, Yasuhiro Igarashi, Masahide Sasaki and Hiroki Shimizu
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii convention center ( 米国ハワイ州ホノルル市)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mannose recognition using pradimicin-functionalized gold nanoparticles2015

    • Author(s)
      榎本賢, 五十嵐康弘, 佐々木正秀, 清水弘樹
    • Organizer
      平成27年度化学系学協会東北大会
    • Place of Presentation
      弘前大学文京キャンパス( 青森県弘前市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 天然有機化合物pradimicinを用いたマンノース認識金ナノ粒子の創成2015

    • Author(s)
      榎本 賢, 五十嵐 康弘, 佐々木 正秀, 清水 弘樹
    • Organizer
      日本農芸化学会2015年度(平成27年度)大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 天然生物活性物質の全合成と ナノクラスター化による天然物利用研究2014

    • Author(s)
      榎本賢
    • Organizer
      第189回農芸化学特別セミナー
    • Place of Presentation
      岡山大学農学部(岡山県岡山市)
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 天然有機化合物pradimicinを利用したマンノース認識金ナノ粒子の創成2014

    • Author(s)
      榎本 賢, 五十嵐 康弘, 佐々木 正秀, 清水 弘樹
    • Organizer
      平成26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      北海道大学農学部(北海道札幌市)
    • Year and Date
      2014-09-22 – 2014-09-23
    • Related Report
      2014 Research-status Report
  • [Remarks] 東北大学 大学院農学研究科・農学部

    • URL

      http://www.agri.tohoku.ac.jp/index-j.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 産業技術総合研究所生物プロセス研究部門

    • URL

      https://unit.aist.go.jp/bpri/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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