Effects of dietary fiber intake on development of Payer's patch in rats

• Project/Area Number: 26850079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Shizuoka University
• Principal Investigator: Hino Shingo 静岡大学, 農学部, 助教 (70547025)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 食物繊維 / パイエル板

Outline of Final Research Achievements

This study aimed to examine the effects of dietary fiber ingestion on intestinal immune system, development of Peyer's patch in particular. In rat study, ingestion of dietary fiber did not affect the number of Peyer's patch in the small intestine. However, dietary fiber increased the size of Peyer's patch in the lower part of small intestine (ileum). Further, our study revealed that ingestion of dietary fiber up regulated expression level of cytokine such as IL-17 and IFN-g. These results indicated that dietary fiber affects immune system in the small intestine.

Research Products

• [Journal Article] High wholegrain barley β-glucan lowers food intake but does not alter small intestinal macronutrient digestibility in ileorectostomised rats (2016)
  • Author(s): Damien P. Belobrajdic, Shingo Hino, Takashi Kondo, Stephen A. Jobling, Matthew K. Morell, David L. Topping,Tatsuya Morita & Anthony R. Bird
  • Journal Title: Int J Food Sci Nutr. Volume: 67 Issue: 6 Pages: 678-685
  • DOI: 10.1080/09637486.2016.1194811
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of allergenic potential for rice seed protein components utilizing a rice proteome database and an allergen database in combination with IgE-binding of recombinant proteins (2016)
  • Author(s): Kana Hirano, Shingo Hino, Kenzi Oshima, Daita Nadano, Atsuo Urisu, Fumio Takaiwa, Tsukasa Matsuda
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 80 Issue: 3 Pages: 564-573
  • DOI: 10.1080/09168451.2015.1116927
  • Peer Reviewed
• [Journal Article] Elemental diet induces the proliferation of sialomucin goblet cells in the rat duodenum and jejunum (2015)
  • Author(s): Shingo Hino , Ayano Ito , Takashi Kondo & Tatsuya Morita
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 未確定 Issue: 6 Pages: 992-6
  • DOI: 10.1080/09168451.2015.1006569
  • Peer Reviewed
• [Presentation] 難消化性デキストリンはラット小腸の 刷子縁膜酵素により実質的に消化される (2016)
  • Author(s): 日野 真吾, 近藤位旨, 稲葉一穂, 森田達也
  • Organizer: 第70回 日本栄養・食糧学会
  • Place of Presentation: 武庫川女子大学（兵庫県西宮市）
  • Year and Date: 2016-05-13
• [Presentation] 新規難消化性縮合糖であるマンナンはラット小腸ムチン分泌を促進する (2016)
  • Author(s): 近藤 位旨, 稲葉 一穂, 日野 真吾, 濱口 徳寿，西村 祐一，尾藤 寛之, 森田 達也
  • Organizer: 第70回 日本栄養・食糧学会
  • Place of Presentation: 武庫川女子大学（兵庫県西宮市）
  • Year and Date: 2016-05-13
• [Presentation] フラクトオリゴ糖摂取時の盲腸IgA分泌応答と粘膜炎症との関連性について (2016)
  • Author(s): 源田 知美, 寺崎 史高, 近藤 位旨，石塚 敏, 日野 真吾, 森田 達也
  • Organizer: 第70回 日本栄養・食糧学会
  • Place of Presentation: 武庫川女子大学（兵庫県西宮市）
  • Year and Date: 2016-05-13
• [Presentation] Pectin and Its Hydrolysates Stimulate Intestinal Mucin Secretion (2015)
  • Author(s): 日野 真吾,寺崎史高,森田達也
  • Organizer: 日本栄養食糧学会、第12回アジア栄養会議（共催）
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-15
  • Int'l Joint Research