| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
An aim of this study is clarification of incretin effect of polymeric polyphenols. It was found that procyanidin as a polymeric polyphenol promote secretion of incretin hormone GLP-1 and adiponectin in plasma 1hour after oral administration to the mice at light period. It was noteworthy that this promotion effect was differ from the administration timing: the effect is weakened when procyanidin was administered at dark period. This difference suggest that insulin secretion by GLP-1 advances phase of clock gene expression. Oral administration of theaflavin, another polymeric polyphenol, promoted secretion of catecholamine. Thus, polymeric polyphenols primarily act to the digestive tract and may contribute to improvement of carbohydrate metabolism through promoting secretion of intestinal hormones and adipocytokines.
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