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Analysis of neuropeptide-receptor signalings that control reproductive nerve center in domestic ruminants

Research Project

Project/Area Number 26850168
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionNagoya University

Principal Investigator

Matsuda Fuko  名古屋大学, 生命農学研究科, 准教授 (10608855)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsヤギ / 視床下部 / 不死化神経細胞株 / KNDyニューロン / 畜産学 / 応用動物 / 神経科学 / 細胞・組織
Outline of Final Research Achievements

We aimed to clarify the neuroendocrine mechanisms that control the reproductive function at cellular level using goats, a good model for ruminants. We focused on KNDy neurons located in hypothalamus, which is thought to be the master regulator of reproductive function and known to secrete 3 neuropeptides, kisspeptin, neurokinin B and dynorphin A. First, we determined the localization of dynorphin receptors in goat hypothalamus. Next, we established an immortalized cell line derived from a goat KNDy neuron. The cell line will be useful to analyze how KNDy neurons are regulated at cellular levels.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Presentation (3 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] Establishment of a Neuronal Cell Line Derived from KNDy Neuron in a Goat.2016

    • Author(s)
      Yuta Suetomi, Ryoki Tatebayashi, Hiroko Tsukamura, Satoshi Ohkura and Fuko Matsuda
    • Organizer
      The 49th Society for the Study of Reproduction Annual Meeting
    • Place of Presentation
      アメリカ合衆国、サンディエゴ
    • Year and Date
      2016-07-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of immortalized neuronal cell lines derived from fetal goat hypothalamus.2014

    • Author(s)
      末富祐太、束村博子、大蔵聡、松田二子
    • Organizer
      The 3rd World Congress on Reproductive Biology
    • Place of Presentation
      イギリス、エジンバラ
    • Year and Date
      2014-09-02 – 2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Establishment of immortalized neuronal cell lines derived from domestic ruminant hypothalamus.2014

    • Author(s)
      末富祐太、加藤雅大、松山秀一、木村康二、束村博子、大蔵聡、松田二子
    • Organizer
      9th International Ruminant Reproduction Symposium
    • Place of Presentation
      帯広
    • Year and Date
      2014-08-25 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 家畜視床下部繁殖中枢由来不死化神経細胞株2015

    • Inventor(s)
      松田二子、大蔵聡
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-243719
    • Filing Date
      2015-12-15
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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