Analysis of neuropeptide-receptor signalings that control reproductive nerve center in domestic ruminants
| Project/Area Number |
26850168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Nagoya University |
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Principal Investigator |
Matsuda Fuko 名古屋大学, 生命農学研究科, 准教授 (10608855)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ヤギ / 視床下部 / 不死化神経細胞株 / KNDyニューロン / 畜産学 / 応用動物 / 神経科学 / 細胞・組織 |
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| Outline of Final Research Achievements |
We aimed to clarify the neuroendocrine mechanisms that control the reproductive function at cellular level using goats, a good model for ruminants. We focused on KNDy neurons located in hypothalamus, which is thought to be the master regulator of reproductive function and known to secrete 3 neuropeptides, kisspeptin, neurokinin B and dynorphin A. First, we determined the localization of dynorphin receptors in goat hypothalamus. Next, we established an immortalized cell line derived from a goat KNDy neuron. The cell line will be useful to analyze how KNDy neurons are regulated at cellular levels.
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Report
(3 results)
Research Products
(4 results)
