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Relarionship among cationic amino acid transporter, protein metabolism, and energy metabolism in porcine skeletal muscle

Research Project

Project/Area Number 26850170
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

Ishida Aiko  国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門 家畜代謝栄養研究領域, 主任研究員 (30414684)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsブタ / 塩基性アミノ酸トランスポーター / タンパク質栄養 / エネルギー不足 / C2C12 / Cat-1 / Cat-2 / リジン欠乏 / IGF-1 / デキサメタゾン / 骨格筋 / タンパク質 / エネルギー / アミノ酸トランスポーター
Outline of Final Research Achievements

Although The expression of Cat-1 mRNA increased in skeletal muscle of pigs fed low protein diet increased, but the expression of Cat-2 mRNA did not change. The expression of Cat-1 mRNA did not change, but the expression of Cat-2 mRNA increased in skeletal muscle of pigs restricted diet. The results of C2C12 experiment suggest that the deficiency of amino acid directly induce the expression of Cat-1 mRNA. Moreover, the results of C2C12 experiment suggest that the increase of Cat-2 expression by restrictive diet was not induced directly by energy restriction, but by low concentration of IGF-1 of serum.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Changes in expression of CAT-1 and CAT-2 mRNA during myogenesis2016

    • Author(s)
      石田藍子
    • Organizer
      The 17th Asian-Australasian of Animal Production Societies Animal Science Congress
    • Place of Presentation
      九州産業大学(福岡県・福岡市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ブタ培養筋肉細胞の分化にともなうCat-1およびCat-2発現量の変化2015

    • Author(s)
      石田藍子、中島一喜、勝俣昌也
    • Organizer
      日本畜産学会第120回大会
    • Place of Presentation
      酪農学園大学キャンパス
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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