Searching analysis for fatty acids stimulate ghrelin secretion in lactating dairy cows

• Project/Area Number: 26850171
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Animal production science
• Research Institution: Utsunomiya University
• Principal Investigator: Fukumori Rika 宇都宮大学, 農学部, 助教 (60721694)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: グレリン / グルカゴン様ペプチド-1 / 消化管ホルモン / 反芻家畜 / 脂肪酸 / 脂質代謝 / インスリン / 成長ホルモン

Outline of Final Research Achievements

Ghrelin, a growth hormone secretagogue, may enhance milk production in lactating cows. We have investigated which nutrients could affect ghrelin secretion, then we found that some fatty acids in the diets increase plasma ghrelin concentraion in cows. However, which fatty acid can stimulate ghrelin secretion had not been cleared. In the present study, we examined the effects of feeding some fatty acids on plasma ghrein concentration and we found that ghrelin secretion is stimulated by medium-chain fatty acids, such as C8:0. In another examination, we investigated the effect of duodenal infusion of individual fatty acids on ghrein secretion, but there was not response to any fatty acids.

Research Products

• [Journal Article] Effects of fat-enriched diet and methionine on insulin sensitivity in lactating cows (2015)
  • Author(s): Fukumori R., Sugino T., Shingu H., Moriya N., Kobayashi H., Yamaji K., El-Sabagh M., Obitsu T., Nagao Y., Taniguchi K., Kushibiki S
  • Journal Title: Journal of Animal Science Volume: 93 Pages: 2778-2784
  • Peer Reviewed
• [Journal Article] Methionine altered insulin sensitivity in lactating cows fed fat-enriched diets (2015)
  • Author(s): R Fukumori, T. Sugino, H. Shingu, N. Moriya, H. Kobayashi, K. Yamaji, M. El-Sabagh, Y. Hasegawa, M. Kojima, K. Kangawa, T. Obitsu, Y. Nagao, K. Taniguchi, and S. Kushibiki
  • Journal Title: Journal of Animal Science Volume: accepted
  • Peer Reviewed
• [Presentation] Effect of duodenal infusion of medium-chain fatty acids on plasma ghrelin concentration in sheep (2016)
  • Author(s): Fukumori R., Takeuchi A., Yanai R., Sarentonglaga B., Ogata K., Yamaguchi M., Hara A., Sato A., Masuda Y, Hasegawa Y., Kojima M., Kangawa K., Sugino T., Nagao Y.
  • Organizer: 17th AAAP congress
  • Place of Presentation: Fukuoka (Japan)
  • Year and Date: 2016-08-22
  • Int'l Joint Research
• [Presentation] ヒツジにおける十二指腸内への単体脂肪酸注入に伴うGLP-1の分泌応答 (2016)
  • Author(s): 福森 理加, 竹内 絢香, 箭内 利菜, サラントラガ, 緒方 和子, 山口 美緒, 原 明日香, 佐藤あかね, 杉野 利久, 長尾 慶和
  • Organizer: 日本畜産学会第121回大会
  • Place of Presentation: 日本獣医生命科学大学
  • Year and Date: 2016-03-28
• [Presentation] Effects of medium-chain fatty acids on plasma concentrations of metabolic hormones and metabolites in lactating cows (2015)
  • Author(s): Fukumori R., Sugino T., Shingu H., Kobayashi H., Nagao Y., Kushibiki S.
  • Organizer: 8th Farm Animal Endocrinology
  • Place of Presentation: Billund (Denmark)
  • Year and Date: 2015-08-26
  • Int'l Joint Research
• [Presentation] Effects of rumen-protected methionine on lipoprotein properties and the response to insulin in lactating cows fed calcium salts of long-chain fatty acids. (2014)
  • Author(s): Fukumori, R., Hinokidani, M., Sugino, T., Shigu, H., Moriya, N., Kobayashi, H., Yamaji, K., Obitsu, T., Nagao, Y., Taniguchi, K., and Kushibiki, S.
  • Organizer: International Symposium on the Nutrition of Herbivores/International Symposium on Ruminant Physiology
  • Place of Presentation: Australia
  • Year and Date: 2014-09-08 – 2014-09-12