| Project/Area Number |
26850181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Tachibana Masato 国立医薬品食品衛生研究所, 食品衛生管理部, 研究助手 (20636831)
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| Research Collaborator |
WATANABE Kenta
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Legionella pneumophila / Paramecium caudatum / 共生 / レジオネラ症 / ゾウリムシ / 解析モデル / 水系感染症 |
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| Outline of Final Research Achievements |
Legionella pneumophila is well kwon as the causative agent of Legionnaires’ disease. The fatality rate of this disease is over 5%. The countermeasure to this bacteria is insufficient because the ecology of this bacteria in environment is not fully clear. It is well known that L. pneumophila can survive in the environment in close association with protists suca as acanthmoeba. This association leads to the replication and spread of L. pneumophila However, mechanisms of infection and endosymbiosis in protistan hosts are not fully understood. Paramecium spp. are appreciated as model organisms for the analysis of cellular and molecular biology, including phagocytosis and exocytosis, and endosymbiosis. This study demonstrated that L. pneumophila has functional systems to control endosymbiosis with paramecium spp.
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