| Project/Area Number |
26850182
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Usui Tatsuya 山口大学, 共同獣医学部, 助教 (80727652)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / DAPK3 / オートファジー / がん / 腸 / DAPK / 肺がん |
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| Outline of Final Research Achievements |
In this study, we hypothesized death associated protein kinase 3 (DAPK3) regulates the development of inflammatory bowel disease through gastrointestinal inframmation and various types of cancer. And we examined the mechanism. DAPK3 promoted cell proliferation and migration of mesenteric arterial smooth muscle cells through activation of p38/HSP27 signals. It was also shown that DAPK3 mediates the development of non-small lung cancer through ERK/c-Myc signal. In addition, DAPK3 regulates autophagy responses through phosphorylation of Beclin 1 at Ser90 in breast cell lines, MCF-7 cells.
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