| Project/Area Number |
26850186
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 循環器・高血圧 / エンドスタチン / 心筋梗塞 / 心肥大 / 筋線維芽細胞 / T型カルシウムチャネル / モノクロタリン / RNA干渉 |
|---|
| Outline of Final Research Achievements |
In the present study, we aimed to clarify the pathophysiological roles of endostatin, a cleaved fragment of type XVIII collagen, in heart disease. We found that endostatin stimulated proliferation and migration of myofibroblasts isolated from the infarct area in a rat myocardial infarction model and inhibited T type calcium channel activity of hypertrophic cardiomyocytes isolated from the right ventricle in a rat monocrotaline-induced right ventricular hypertrophy model. We also clarified that endostatin had cardioprotective effects on these heart diseases.
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