| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In dogs with spinal cord injury, the blood concentration of pNF-H increased within a week after the onset and the value can be a promising biomarker to evaluate the prognosis after spinal cord injury. On the other hand, in acute phase, GFAP showed good specificity as a prognostic factor. Analysis of in vivo pNF-H kinetics revealed elimination half-life of pNF-H was estimated to 190 min. In conclusion, interventions have little influence on serum pNF-H and the time-course changes in serum pNF-H indicate the simultaneous pNF-H leakage from damaged spinal cord in the process of injury or restoration. This result suggested that evaluating blood concentration of pNF-H after spinal cord injury can offer good information to decide post-surgical care and rehabilitative therapy. We are also uniquely developing ELISA system to detect canine pNF-H in blood to use in daily clinics.
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