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Study on prevention of perioperative hypothermia by amino acid in dogs

Research Project

Project/Area Number 26850197
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionGifu University

Principal Investigator

SHIBATA Sanae  岐阜大学, 応用生物科学部, 准教授 (20588917)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords犬 / アミノ酸輸液 / 周術期低体温 / 周術期 / 骨格筋 / オクトレオチド / 犬骨格筋細胞 / アミノ酸 / インスリン
Outline of Final Research Achievements

Amino acid infusion in dogs inhibited insulin secretion reduced the effect which attenuates the decrease in body temperature during anesthesia. Therefore, in healthy dogs, amino acid infusion can attenuates the decrease in body temperature during anesthesia by facilitating insulin secretion. In skeletal muscle and liver derived from dogs infused amino acids, Akt-mTOR pathway was activated. In addition, Akt-mTOR pathway in skeletal muscle can be activated without insulin.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2018 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Intravenous infusion of amino acids in dogs attenuates hypothermia during anaesthesia and stimulates insulin secretion.2016

    • Author(s)
      Takashima, S., Shibata, S., Yamada, K., Ogawa, M., Nishii, N. and Kitagawa, H.
    • Journal Title

      Veterinary Anaesthesia and Analgesia

      Volume: 43(4) Issue: 4 Pages: 379-387

    • DOI

      10.1111/vaa.12319

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 小型犬における周術期低体温に対するアミノ酸輸液の有効性2018

    • Author(s)
      長井里帆,傍島由布子,下岡由佳,髙島諭,柴田早苗
    • Organizer
      日本獣医麻酔外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 麻酔中の犬へのアミノ酸輸液による体温低下軽減に対するインスリンの関与2016

    • Author(s)
      傍島由布子 北村真麻 市川哲 下岡由佳 菅井里子 髙島諭 西飯直仁 北川均
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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