| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
The transition metal-catalyzed asymmetric cyclopropanation reaction of alkenes with diazo compounds represents one of the most powerful means for the construction of optically active cyclopropane building blocks. Hansen and co-workers developed highly diastereoselective cyclopropanations of alkenes with halodiazoacetates, but the asymmetric induction was below 10% ee.
The cyclopropanation with bromodiazoacetophenone under catalysis by Rh2(S-TBPTTL)4 produced cis-cyclopropene product in 75% yield with 85% ee. In addition, it was found that the reaction with chlorodiazoacetophenone afforded the corresponding cyclopropene with 91% ee.
|
