Synthetic studies on polycyclic alkaloids based on development of cascade reactions
| Project/Area Number |
26860004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
Ueda Hirofumi 東北大学, 薬学研究科, 助教 (50581279)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 有機化学 / 薬学 / 生物活性天然物 / 全合成 / アルカロイド / カスケード反応 / キノリン / ステモナアルカロイド / 天然物合成 / 多環性複素環 / ステニン / Mannich反応 / Michael反応 / 金触媒 / カスケード型連続反応 / 酸化反応 / 多環性高次構造 |
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| Outline of Final Research Achievements |
We undertook synthetic studies on highly fused polycyclic alkaloids such as isoschizogamine, stenine and its congeners via original cascade cyclization reactions. Thus, we developed synthetic methodologies for concise constructions of highly functinalized quinoline skeleton and tricyclic skeleton including pyrroloazepine moiety, which are found in natural compounds. Furthermore, we achieved an asymmetric total synthesis of (-)-isoschizogamine by using the synthetic intermediate derived via the cascade cyclization reaction.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Structural and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.2016
Author(s)
Morita J, Kano K, Kato K, Takita H, Skagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 20995-20995
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] T988類の全合成2015
Author(s)
佐藤壮一郎，平山梓，植田浩史，徳山英利
Organizer
日本薬学会第135年会
Place of Presentation
神戸学院大学(兵庫県、神戸市)
Year and Date
2015-03-25 – 2015-03-28
Related Report
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[Presentation] Total Syntheses of T988 B and C2014
Author(s)
Soichiro Sato, Azusa Hirayama, Hirofumi Ueda, Hidetoshi Tokuyama
Organizer
The Fourth Joint Campus Asia Symposium
Place of Presentation
Sendai, Japan
Year and Date
2014-11-26 – 2014-11-27
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