| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We undertook synthetic studies on highly fused polycyclic alkaloids such as isoschizogamine, stenine and its congeners via original cascade cyclization reactions. Thus, we developed synthetic methodologies for concise constructions of highly functinalized quinoline skeleton and tricyclic skeleton including pyrroloazepine moiety, which are found in natural compounds. Furthermore, we achieved an asymmetric total synthesis of (-)-isoschizogamine by using the synthetic intermediate derived via the cascade cyclization reaction.
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