Carbon-carbon bond formation reaction by using Pt complex containing non-innocent ligand

• Project/Area Number: 26860006
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: Toho University
• Principal Investigator: KIKKAWA Shoko 東邦大学, 薬学部, 助教 (30625017)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 反応化学 / 酸化還元 / 反応開発 / 錯体

Outline of Final Research Achievements

In this study, carbon(sp3)-carbon(sp3) and carbon(sp3)-CN bond formation using a catalytic amount of platinum complex containing redox-active ligands is realized. The process involves a CDC-type bond formation and proceeds efficiently under air atmosphere with Pt(II)-bis(ortho-semibenzoquinonate) complex as a catalyst. Among a variety of solvents tested, dimethyl sulfoxide was found to be the best. However it is suggested that the reaction underwent without Pt-catalyst under mild conditions. Disappointingly the possible involvement of trace amounts of metal complexes in the reaction mixture that were catalyzing our process cannot be completely eliminated.