| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Furofuran lignans isolated from various vascular plants have been reported to exhibit antitumor, antioxidant, antiviral, and antihypertensive activities, as well as inhibition of low-density lipoprotein oxidation. These furofuran lignans and their derivatives are expected to be useful as lead compounds for drug development.
In this research, plant products (+)-hedyotol A, (+)-sesamin, (+)-sesaminol, (+)-methylpiperitol, (+)-aschantin, and (+)-5'-hydroxymethylpiperitol were synthesized in a highly stereocontrolled manner through proline-catalyzed cross-aldol reaction, followed by biomimetic construction of the furofuran lignan skeleton through a quinomethide intermediate.
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