| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Toward the total synthesis of marine toxin spirolide D, the stereoselective construction of BCD fragment has been explored. Transannular spiroketalization of the triketone with a tether between the carboxyl group at C10 and hydroxyl group at C24 proceeded stereoselectively to give the desired stereoisomer in good yield. Since the reaction using acyclic triketone gave desired stereoisomer as the major product, the stereoselectivity of this process is rationalized by a preferred dipole orientation. The product was successfully converted to the BCD ring fragment through a stereoselective hydrogenation of C11-C12 double bond.
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