Research Project
Grant-in-Aid for Young Scientists (B)
We report on the design and synthesis of amphiphilic and luminescent tris-cyclometalated Ir complexes that work as inducers and detectors of cell death. Ir complexes containing cationic peptides such as a KKGG sequence and alkyl chain linkers of adequate length (C6 and C8) exhibit considerable cytotoxicity against Jurkat cells. Mechanistic studies suggest that Ir complexes containing the KKGG peptide interact with anionic molecules on the cell surface and/or membrane receptors to trigger the Ca2+ dependent pathway and intracellular Ca2+ response, resulting in necrosis accompanied by membrane disruption.
All 2016 2015 2014
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Invited: 4 results) Book (1 results)
Inorganic Chemistry
Volume: 55 Issue: 8 Pages: 3829-3843
10.1021/acs.inorgchem.5b02872
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume: 64 Pages: 451-464
130005148749
Bioconjugate Chemistry
Volume: 26 Issue: 5 Pages: 857-879
10.1021/acs.bioconjchem.5b00095
Volume: 54 Issue: 11 Pages: 5342-5357
10.1021/acs.inorgchem.5b00369