Design and synthesis of metallodrugs based on self-assembly systems
Project/Area Number |
26860016
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Chemical pharmacy
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Research Institution | Tokyo University of Science |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | がん治療薬 / イリジウム錯体 / カチオン性ペプチド / 細胞死 / 金属錯体 / イリジウム / トリスビピリジン錯体 / がん細胞 / カルシウム / 自己集積 |
Outline of Final Research Achievements |
We report on the design and synthesis of amphiphilic and luminescent tris-cyclometalated Ir complexes that work as inducers and detectors of cell death. Ir complexes containing cationic peptides such as a KKGG sequence and alkyl chain linkers of adequate length (C6 and C8) exhibit considerable cytotoxicity against Jurkat cells. Mechanistic studies suggest that Ir complexes containing the KKGG peptide interact with anionic molecules on the cell surface and/or membrane receptors to trigger the Ca2+ dependent pathway and intracellular Ca2+ response, resulting in necrosis accompanied by membrane disruption.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Supramolecular Complexes Formed by the Self-Assembly of Hydrophobic Bis(Zn2+-cyclen) Complexes, Copper, and Di- or Triimide Units for the Hydrolysis of Phosphate Mono- and Diesters in Two-phase Solvent Systems (Cyclen = 1,4,7,10-Tetraazacyclododecane)2016
Author(s)
Yosuke Hisamatsu, Yuya Miyazawa, Kakeru Yoneda, Miki Miyauchi, Mohd Zulkefeli, and Shin Aoki
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Journal Title
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume: 64
Pages: 451-464
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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