| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this project, the new methodology to construct heterocyclic framework found in the structure of biologically active compounds and natural proudcts. This reaction is bond forming reaction between olefin and nucleophile. The products of this reaction are nitrogen heterocycles such as pyrrolidine and pyperidine, and oxygen heterocycles such as cycilc ether and lactone. A cobalt catalyst, electrophilic fluorine reagent, and siloxane ragent are required in this reaction. The powerful and excellent functional group torerant reaction showed broad substrate scope.
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