Chiral tetracyanocyclopentadienides for catalytic asymmetric reactions
| Project/Area Number |
26860018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
Sakai Takeo 名城大学, 薬学部, 助教 (90583873)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 有機化学 / 超強酸共役塩基 / テトラシアノシクロペンタジエニド / 酸触媒 / 回転異性体 / ロータマー / 触媒 / 不斉反応 / アルドール / マンニッヒ / 不斉アニオン |
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| Outline of Final Research Achievements |
Tetracyanocyclopentadienides having chiral binaphthyl auxiliaries has been developed as a new class of asymmetric superacid conjugate bases. The sodium tetracyanocyclopentadienides had a catalytic activity for a Mukaiyama aldol reaction and an addition reaction on acyl isoquinolinium salts, in which the reaction products had a few enantiomeric excess. In the chiral anions having an ester linker, two rotamers around C(Ar)-O bond in an aryl ester were observed at room temperature, that is a rare phenomenon for aryl esters. The rotation barriers were measured with a line-shape analysis on VT-NMR.
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Report
(3 results)
Research Products
(35 results)
