| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In this study, we elucidated spheronization mechanism of drug crystals through extremely-high shearing using a mechanical powder processor. In addition, we investigated the relationships between spheronization and mechanical properties of drug crystals. Strong crystals were mechanically spheronized by layering granulation of relatively large particles resulted from partial destruction of drug crystals. Meanwhile, weak crystals became spherical particles by agglomeration of fine powder generated through pulverization of drug crystals. Low-cohesive powder did not undergo layering granulation or powder agglomeration not to be spheronized. Therefore, we concluded that the success or failure of mechanical spheronization is determined by cohesiveness of drug powder.
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