| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Glucocorticoids (GCs) are the most commonly used anti-inflammatory drugs against refractory inflammatory disease. Despite the enormous efforts in elucidating the glucocorticoid-induced anti-inflammatory response, the control mechanism of overactive inflammatory response by GCs is not understood. GCs are known to exert their anti-inflammatory effects by binding to glucocorticoid receptor (GR), leading to the expression regulation of pro- and ant-inflammatory regulators.
This study focused the transcriptional activity of GR and performed the high-throughput screening of the GR transcriptional activator with luciferase assay and human cDNA expression library (6000 clone) for purpose of elucidating the control mechanism of overactive inflammatory response by GCs. From our screening, some genes were predicted as GR transcriptional activators including cofactor.
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