| Project/Area Number |
26860036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 時計遺伝子 / 転写因子 / 概日リズム |
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| Outline of Final Research Achievements |
Circadian rhythms, biological oscillation with a period of about 24 hours, are maintained by a timekeeping system composed of the various molecular basis among circadian genes. Although small compounds that affect the clock function would apply for therapeutic strategies of physiological and metabolic disorders, there are few compounds identified that high selectively target of clock proteins. In this study, we identified a novel small molecule that specifically induced period1 (Per1) expression, resulting in shortening of the circadian period. Further, we revealed that this compound abolished the ability of transcriptional repressive function of cryptochrome (Cry) through the direct interaction with Cry protein used by MS analysis. Our data suggest this compound would be a tool for understanding the molecular basis of clock genes, and helpful for developing small compounds targeted at clock-based therapeutic of diseases.
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