Research on fertility improvement using cyclodextrins
| Project/Area Number |
26860039
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Takeo Toru 熊本大学, 生命資源研究・支援センター, 講師 (10517014)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 不妊 / シクロデキストリン / 精子 / 受精能獲得 / コレステロール / リン脂質 / 生体膜 / 体外受精 / 環状オリゴ糖 / 脂質 / 超活性化 / 不妊治療薬 / 受精 / 生体膜脂質 / リピッドラフト / 低受精能 / 不妊治療 |
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| Outline of Final Research Achievements |
The number of subfertile and infertile patients is increasing in advanced countries. However, there is no innovative solution to improve their fertility. In this study, we examined the effect of cyclodextrins on the functions of mouse sperm. Methyl-beta-cyclodextrin enhanced fertility and promoted acrosome reaction and hyperactivation by enhancing membrane fluidity with the reduction of cholesterol in sperm membrane. Dimethyl-alpha-cyclodextrin also increased fertility of sperm by induction of lipids efflux from sperm membrane. These results suggest that cyclodextrins is applicable as fertility activator in the in vitro fertilization.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Cysteine analogs with a free thiol group promote fertilization by reducing disulfide bonds in the Zona Pellucida of mice2015
Author(s)
Takeo, T., Horikoshi, Y., Nakao, S., Sakoh, K., Ishizuka, Y., Tsutsumi, A., Fukumoto, K., Kondo, T., Haruguchi, Y., Takeshita, Y., Nakamuta, Y., Tsuchiyama, S. and Nakagata, N.
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Journal Title
Biol. Reprod.
Volume: 92(4)90
Issue: 4
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 生殖工学と薬学の融合が拓く世界2014
Author(s)
竹尾 透
Organizer
第8回次世代を担う若手医療薬科学シンポジウム
Place of Presentation
熊本大学薬学部（熊本県）
Year and Date
2014-11-15 – 2014-11-16
Related Report
Invited
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