The functional regulation of Reelin and its application to drug discovery
| Project/Area Number |
26860043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Kohno Takao 名古屋市立大学, 薬学研究科(研究院), 助教 (70581742)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳 / リーリン / プロテアーゼ / 大脳皮質 / dab1 / プロテオリシス / 神経細胞移動 / 樹状突起 |
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| Outline of Final Research Achievements |
Reelin is glycoprotein that is essential for normal brain formation and function. The hypofunction of Reelin is related to neuropsychiatric disorders.
We found that Reelin is cleaved within its C-terminal region and this cleavage regulates position and dendrite development of upper-layer neurons. Furthermore, we found the upregulation of Reelin activity by inhibition of Reelin cleavage does not affect the neuronal layer formation in embryonic stages.
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Report
(3 results)
Research Products
(36 results)
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[Presentation] Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis2015
Author(s)
Takao Kohno, Takao Honda, Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima, and Mitsuharu Hattori.
Organizer
Society for Neuroscience, Neuroscience 2015 meeting,
Place of Presentation
McCormick Place
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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