Investigatation the roles of GPR4 in myocardial infarction
| Project/Area Number |
26860056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
NAGASAKA AKIOMI 九州大学, 薬学研究科(研究院), 助教 (10723877)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | GPR4 / プロトン感知性受容体 / 心筋梗塞 / ＧＰＲ４ |
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| Outline of Final Research Achievements |
GPR4 is a receptor which recognizes extracellular protons. Because pH of the heart at the time of myocardial infarction (MI) falls, we produced MI model mice with wild type and GPR4 deficient mice to investigate the roles of GPR4 in MI. We found that GPR4 deficient mice showed a decrease of survival rate and cardiac functions. We also identified GPR4 expressing cells which involved in inflammation after MI.
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Report
(3 results)
Research Products
(4 results)
